- James Roday (plays Shawn Spencer) also a Psych producer since 2009, and has written and directed episodes of Psych as well. Currently dating Psych co-star Maggie Lawson.
- Dulé Hill (plays Burton "Gus" Guster also a producer of Psych since 2009. Has been an understudy on Broadway, and in other works such as Holes, 10.5, and The West Wing.
- Timothy Omundson (plays Carlton Lassiter), also known for his roles as Sean Potter on Judging Amy and Eli on Xena: Warrior Princess.
- Maggie Lawson (plays Juliet O'Hara) has also appeared in Gamer, Crumbs, and Inside Schwartz. She is currently dating Psych co-star James Roday.
- Kirsten Nelson (plays Karen Vick) founding member of Chicago's Roadworks Theatre Ensemble, has also been featured in Buffy the Vampire Slayer, The Fugitive, and The West Wing.
- Corbin Bernsen (plays Henry Spencer) is a long time actor, best known for not only his role on Psych, but also on L.A. Law, and the films Major League and Major League II.
- Liam James (plays Young Shawn Seasons 1-5) is a Canadian Child Actor best known for his role as Young Shawn on Psych, Noah Curtis in the film 2012, and Jack Linden on The Killing.
- Skyler Gisondo (plays Young Shawn Seasons 5-Present) is an American child actor best known for his role as Young Shawn on Psych, Bryan Pearson on The Bill Engvall Show, and Tommy Doyle in Halloween. In 2009, Gisondo won a "Young Artist Award - Outstanding Young Performer in a TV Series" for his role on The Bill Engvall Show.
- Carlos McCullers II (plays Young Gus) is an American Child Actor best known for portraying Young Gus on Psych.
- Sage Brocklebank (plays Buzz McNab) is a Canadian Actor and professional Poker Player. Along with his role as Buzz McNab on Psych, he has also played roles in How I Married My High School Crush and Smallville.
- Cybill Shepherd (plays Madeleine Spencer) is an American Actress, Singer, and former Model. She has best known for her appearances in Taxi Driver, The Last Picture Show, Cybill, and The L Word.
- Rachael Leigh Cook (plays Abigail Lytar) is an actress, model, voice artist and producer. She is known for her appearances in Psych, She's All That, Josie and the Pussycats, and Perception.
- Phylicia Rashad (plays Winnie Guster) is dubbed "the mother" of the African-American community at the 42nd NAACP Image Awards. She is known for her long-time role as Claire Huxtable on The Cosby Show. She has recieved numerous awards over the years, including the Tony Award for Best Performance by a Leading Actress in a Play (the first African-American Actress to do so).
- Ally Sheedy (plays Mr. Yang) is an actress and author, who is best known for her roles in The Breakfast Club, St. Elmo's Fire, WarGames, and Short Circuit.
- Jimmi Simpson (plays Mary Lightly) is an actor known for his roles on Psych, It's Always Sunny in Philadelphia, 24, and Date Night.
- Kristy Swanson (plays Marlowe Viccellio) is an actress known for her roles in Buffy the Vampire Slayer and Fires in the Attic.
This category has the following 3 subcategories, out of 3 total.
Pages in category "Cast"
The following 170 pages are in this category, out of 170 total.